Advanced Countermeasures to prevent a Ddos

I was wondering if anyone on this list has considered the idea of trying to
eliminate Ddos attacks while designing their Data Centre's network topology.
If so, did you include server isolation and or distribution?

Secondly, is it even possible to eliminate (or as close to elimination as
one can have in the tech world) Ddos attacks with network design and server
implementation. Does anyone have an advanced understanding of these issues
and if so are you willing to exchange information off-line?

Scott E. MacKenzie